Ras
H-Ras, N-Ras, K-Ras4B express in the brain. H-Ras expresses preferentially in the brain. Kockout of K-Ras4B is lethal. There is not much phenotype in H/N-Ras knockout.
Lack of Amygdala-dependent emotional conditioning. No effects on hippocampus-dependent memory. Ras-GRF Activates Ha-Ras, but Not N-Ras or K-Ras 4B in a calcium dependent manner (Jackson, JBC98)
- MAPK cascade signaling and synaptic plasticity (NRN, Huganir) Must read.
